风湿病学研究
风湿病学研究
的 风湿病学 Division has an active basic and clinical research program in the field of Systemic Lupus Erythematosus (SLE) headed by Dr. 乔治Tsokos. 实验室, 哪个是大于6的,000平方英尺的长凳空间, is located in the Clinical Life Science Building.
的 狼疮卓越中心 supports basic and translational studies in SLE and provides clinical care to patients across multiple disciplines such as rheumatology, 肾内科和皮肤科.
Investigations are supported by highly competitive grants from the National Institutes of Health, 国防部, and additional funding from foundations and pharmaceutical companies. 目前资金超过3亿美元.每年6亿美元.
研究 activities within the Division include:
- Study of immune cell signaling events in patients with systemic lupus erythematosus
- Study of regulatory T cells in patients with autoimmune diseases
- Study of Il-17 producing cells in autoimmune diseases
- Study of mechanisms that are involved in the development of lupus nephritis
- Studies to understand the propensity of patients with lupus to infections
- Study of the role of complement in the expression of tissue damage
- Preclinical studies in lupus-prone mice and other engineered mice to characterize disease mechanisms and to develop novel therapeutics
实验室 uses a broad range of approaches including:
- 患者材料的使用
- Lupus-prone老鼠
- 基因工程小鼠
- 代谢组学
- RNA sequencing and single cell sequencing
- 生物信息学
了解更多有关 Tsokos实验室.
Representative 审查s Describing Ongoing Lab Projects
- 免疫足细胞. Bhargava R, Tsokos GC. 当前观点:风湿病. 2019年3月31日(2):167-174. doi: 10.1097 / BOR.0000000000000578.
- Signaling lymphocyte activation molecule family in systemic lupus erythematosus. Comte D, Karampetsou MP, Humbel M, Tsokos GC. 中国Immunol. 2018年11月8日. pii: s1521 - 6616 (18) 30442 - x. doi: 10.1016/j.这一.2018.11.001. [印前Epub]
- Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells. Ferretti AP, Bhargava R, Dahan S, Tsokos MG, Tsokos GC. 前面Immunol. 2018年10月1日;9:2113. doi: 10.3389 / fimmu.2018.02113. eCollection 2018. 审查.
- Regulatory T cells in the treatment of disease. Sharabi A, Tsokos MG, Ding Y, Malek TR, Klatzmann D, Tsokos GC. Nat Rev药物发现. 2018年10月12日. doi: 10.1038 /”.2018.148. [印刷前的Epub]回顾.
- Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus. Katsuyama T, Tsokos GC, Moulton VR. 前面Immunol. 2018年5月17日9:10 . 88. doi: 10.3389 / fimmu.2018.01088. eCollection 2018. 审查.
- Targeting Regulatory T Cells to Treat 病人s With Systemic Lupus Erythematosus. Mizui M, Tsokos GC. 前面Immunol. 2018年4月17日;9:786. doi: 10.3389 / fimmu.2018.00786. eCollection 2018. 审查.
- SLE-Associated Defects Promote Altered T Cell Function. Crispin JC, Hedrich CM, Suárez-Fueyo A, Comte D, Tsokos GC. Crit Rev immuno1. 2017;37(1):39-58. doi: 10.1615 / CritRevImmunol.2018025213. 审查.
- Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective. Moulton VR, Suarez-Fueyo A, Meidan E, Li H, Mizui M, Tsokos GC. Mol Med趋势. 2017年7月;23 (7):615 - 635. doi: 10.1016/j.molmed.2017.05.006. 2017年6月13日. 审查.
- T cells and autoimmune kidney disease. Suárez-Fueyo A, Bradley SJ, Klatzmann D, Tsokos GC. Nat Rev Nephrol. 2017年6月,13 (6):329 - 343. doi: 10.1038 / nrneph.2017.34. 2017年3月13日. 审查.
- DNA methylation in systemic lupus erythematosus. Hedrich CM, Mäbert K, Rauen T, Tsokos GC. 表观基因组学. 2017年4月,9 (4):505 - 525. doi: 10.2217 / epi - 2016 - 0096. Epub 2016年11月25日. 审查.
- New insights into the immunopathogenesis of systemic lupus erythematosus. Tsokos GC, Lo MS, Costa Reis P, Sullivan KE. 风湿醇. 2016年11月22日;12(12):716-730. doi: 10.1038 / nrrheum.2016.186. 审查.
- What rheumatologists need to know about innate lymphocytes. Exley MA, Tsokos GC, Mills KH, Elewaut D, Mulhearn B. 风湿醇. 2016年11月,12 (11):658 - 668. doi: 10.1038 / nrrheum.2016.140. Epub 2016年9月2日. 审查.
- T cells in Systemic Lupus Erythematosus. Suárez-Fueyo A, Bradley SJ, Tsokos GC. 当前的意见免疫. 2016年12月,43:32-38. doi: 10.1016/j.细胞色素氧化酶.2016.09.001. 2016年9月13日. 审查.
- Empowering Regulatory T Cells in Autoimmunity. Kasper IR, Apostolidis SA, Sharabi A, Tsokos GC. Mol Med趋势. 2016年9月,22 (9):784 - 797. doi: 10.1016/j.molmed.2016.07.003. 2016年7月25日. 审查.
- Pathogenesis and targeted treatment of skin injury in SLE. 邓GM, Tsokos GC. 风湿醇. 2015年11月,11 (11):663 - 9. doi: 10.1038 / nrrheum.2015.106. Epub 2015 8月4日. 审查.
- T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity. Moulton VR, Tsokos GC. J临床投资. 2015年6月,125 (6):2220 - 7. doi: 10.1172 / JCI78087. Epub 2015年5月11日. 审查.
- Gene-function studies in systemic lupus erythematosus. Crispín JC, Hedrich CM, Tsokos GC. 风湿醇. 2013年8月,9 (8):476 - 84. doi: 10.1038 / nrrheum.2013.78. Epub 2013年6月4日. 审查.
- 系统性红斑狼疮. Tsokos GC. [英]医学. 2011年12月1日;365(22):2110-21. doi: 10.1056 / NEJMra1100359. 审查