David Linehan，医学博士

普通外科住院医师 Program alumnus
Chairman of 手术, University of Rochester Medical Center
Professor of 手术, University of Rochester

“I learned about a life of service and academic excellence." 

Even as a teenager, Boston native David Linehan，医学博士, knew he wanted to be a 医生. His early career choice was influenced by his mother, who founded and ran a rehabilitation facility for men with alcohol and drug addictions, 以及他就读的耶稣会高中. 从这两方面来看，Dr. Linehan,“我 learned about a life of service and academic excellence.”

Service and academic excellence have always defined Dr. Linehan的职业生涯. A 1997 graduate of the department’s 普通外科住院医师 Program, Dr. Linehan was recently named Chair of 手术 at the University of Rochester Medical Center, a position he assumes on October 1. 他以前是 Neidorff家族和Robert C. Packman Professor of 手术 at Washington 圣何塞大学医学院. 路易斯，从那以后他一直在那里工作 completing a surgical oncology fellowship at Memorial Sloan-Kettering 1999年癌症中心.

自2007年以来，. Linehan served as Chief of the Division of Hepatobiliary, 胰腺癌,
胃肠 手术 at Washington University School of 医学 and Barnes-Jewish Hospital, where he maintained a high-volume clinical practice 主要关注癌症患者. 他也是HPB/GI的主任 Fellowship Training Program, one of the most
competitive such fellowships in the nation.

Dr. Linehan devotes nearly half of his time to translational research aimed 在寻找一本小说时，
effective treatment for pancreatic cancer, one of the deadliest 恶性肿瘤. For the past 15 years he has focused on understanding the intricacies of the pancreatic tumor microenvironment.

This work led to his discovery that pancreatic tumors mobilize stromal cells from the bone marrow and that these cells, which suppress the immune response, play a key role in the growth and spread of tumors. “We hypothesized that if we could block these cells, we could reverse the immunosuppression and improve the effectiveness of chemotherapy,”
博士解释说. Linehan.

Using a drug called a CCR2 inhibitor, which prevents the mobilization of 这些来自骨髓的细胞. Linehan和他的团队证明了这一点 临床前模型的疗效. The drug is now being evaluated in patients 患有局部晚期胰腺癌. “这很令人兴奋 concept developed in our lab is now in [phase 2] clinical trials,” he says.

去年，Dr。. Linehan收到了1美元.2500万RO1拨款，“CCR2封锁” in Human Pancreatic Cancer,” from the National Institutes of Health to take 这项研究进入了下一个阶段. 今年，他被任命为 multi-institutional Stand Up To Cancer (SU2C) Pancreas Cancer “Dream Team” to further pursue this area of investigation.

Dr. Linehan’s commitment to all domains of academic surgery — patient care, 教学,
research — was inspired by his experiences as a surgical resident. A graduate of Dartmouth College and the University of Massachusetts Medical 学校,博士. Linehan is grateful to have trained under Glenn Steele Jr., MD, 博士学位. “Dr. Steele was a fantastic role model — a true triple threat: an outstanding administrator, researcher, and surgeon,” says Dr. Linehan. “He set a tone and standard that many of us benefited from.”

Dr. Linehan says he also benefited from the broad and diverse training and research opportunities offered by the 金宝搏手机登录 surgical residency, which he 被形容为“波士顿最好的”.在他的住院医师生涯中. Linehan花 two years in a research fellowship in tumor immunotherapy at Brigham and Women’s Hospital with Timothy Eberlein, MD.

Dr. 埃伯莱因招募了奥巴马博士. 林汉至圣. 路易斯，现在是 手术 at Washington University School of 医学. 尽管他的行李很紧 schedule, which also includes serving in leadership roles in numerous professional societies and as an editorial board member of
《金博宝官网登录》. Linehan, a married father of two teenaged sons, still finds time to return to New England every year, where he enjoys visiting family, downhill skiing, fishing, and spending time at his summer home on 缅因州海岸. 但即使在他放松的时候. 莱恩汉的目标是寻找 a better treatment or even a cure for pancreatic cancer — is never far from 他的思想.